Sentence examples for mediated by sequence from inspiring English sources

MEDUSA is an algorithm that uses boosting to learn cis regulatory motifs and builds a gene regulatory program from promoter sequence and gene expression data, using the expression levels of known transcriptional regulators and signal transducers to help predict the differential expression of target genes as mediated by sequence motifs.

As mentioned before, the individual phenotype is known to be shaped by phenomena that are or are not mediated by sequence variations in DNA, i.e. inheritance is both genetic and environmental, with the latter primarily relying on the quality of mother-infant interaction [52].

These results suggest that multiple MITE families may originate from a single ancestral autonomous element, and formation of MITEs can be mediated by sequence microhomology.

Previous research suggested that the evolution of RGA clusters is usually mediated by sequence exchange, tandem duplication, segmental duplication, or gene conversion [ 9, 23, 24].

Presumably, the central CDSs have been transferred horizontally into the center of the locus and then exchanged through homologous recombination mediated by sequence conservation in the outer CDSs.

The overall implication is that cleavage specificity is mediated by sequence-dependent DNA deformations that influence the scissile phosphate positioning and reactivity.

(These results are shown in Figure S5) Thus, rescue is not simply due to expression of an exogenous gene; it is mediated by sequence-specific features of Syn-IlvA-1.

3) Upon induction mediated by sequence-specific DNA binding proteins, a much larger amount of P-TEFb is recruited to the locus, which can phosphorylate CSpt5 (and NELF) to remove the repressive effect, which in turn allows the phosphorylation of RNAPII CTD, thereby allowing assembly of additional accessory factors for productive elongation.

These data are consistent with a mechanism for MEOX2-driven induction of senescence that requires both DNA binding and transcriptional activation, mediated by sequences between a.a. 85 and 186, in addition to the homeodomain.

Transcription initiation regulation is mediated by sequence-specific interactions between DNA-binding proteins (transcription factors) and cis-elements, where BRE, TATA, INR, DPE and MTE motifs constitute canonical core motifs for basal transcription initiation of genes.

In protein interaction networks, the pairwise binding of proteins is directly mediated by sequences, and natural selection can act to maintain complementary sequences in two interacting proteins [ 45].