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We conclude that initial adherence of MDCK cells to a collagen I substratum is mediated by peripheral actin filaments and adhesion complexes regulated by MLCK but not by stress fibers and adhesion complexes controlled by RhoA.
In preclinical studies, the combination of chronic stress and a high sugar/fat diet is a more potent driver of visceral adiposity than diet alone, a process mediated by peripheral neuropeptide Y (NPY).
We cannot be certain whether pain propagation and pain direction in each type is mediated by peripheral or central mechanisms.
Current exercise guidelines are focused predominantly on aerobic programs despite evidence that age-associated declines are mediated by peripheral tissue changes.
Other studies recently showed a control of HIV-1 replication in dendritic cells mediated by peripheral blood NK cells [33].
It is established that dynamic mechanical allodynia is mediated by peripheral low-threshold, large myelinated Aβ-fibers [7] [9].
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Furthermore, we detected an anti-hyperalgesic effect of AM1241 when the experimental paradigm was represented by phase II of formalin test in NTG treated animals, i.e. a condition of hyperalgesia mediated by the peripheral release of inflammation mediators and by central modulation.
However, our data revealed a new action of caffeine – inhibition of acupuncture-induced analgesia that is mediated by antagonizing peripheral adenosine receptors at the acupuncture point, even at low doses.
Upon thaw, the pre-labeled cells displayed viability and label retention comparable to freshly labeled cells, responded to ADCC mediated by both peripheral blood mononuclear cells and engineered natural killer cells, performed stably for at least 3 years and provided favorable precision and accuracy to ADCC assays.
Our experiments, for the first time, revealed that the anti-morphine effect of pDBIs and bDBI-16 is mediated by the peripheral type of BDZ receptor, while the morphine-enhancing effect of bDBI-19 is mediated by the central type of BDZ receptor (Fig. 2E and 2F).
Previous studies suggest that these effects are mainly mediated by the peripheral opioid receptors [ 14- 16].
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