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The second phase is mediated by ongoing stimulation of nociceptors by inflammatory mediators (serotonin, histamine, bradykinin, NO, and prostaglandins) released from injured tissue, leading to activity-dependent sensitization of CNS neurons within the dorsal horn [ 31].
Moreover, by counting the total amount of paw flinches that is believed to be mediated by ongoing primary afferent input, it was shown that 87.35±5.36, 170.50±9.15 and 305.80±20.13 flinches were induced by 0.2 mg BV for a period of 5, 10 and 20 min, respectively.
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From first principles, segregation could be considered to be mediated by adaptation to the ongoing background statistics and detection of the figure as a deviation from this established pattern.
Treatment with natalizumab may also inhibit the ongoing inflammation mediated by leukocytes already present in the CNS by interrupting their interaction with the extracellular matrix proteins [ 67].
These results therefore suggest a new role for chondrocytes during RA in the retention of lymphocytes in the joint in supporting an inflammatory milieu and in stimulating ongoing inflammation mediated by TNF-β/NF-κB signaling.
The consequences of these oxidative processes during sepsis may be ongoing cell damage mediated by reactive oxygen and nitrogen oxide species that culminates in multisystem organ failure.
H3K36 methylation mediated by Set2-type methyltransferases occurs as a consequence of ongoing transcription, so the distribution of this modification observed in mixed cell populations is likely to be dominated by its cotranscriptional addition.
In all somatic cells, there is a delicate balance between ongoing levels of DNA damage and repair activity mediated by constitutively expressed DNA repair proteins.
Final confirmation that the inhibition of super-infection was mediated by the hepcidin-iron axis was obtained in mice with no ongoing blood-stage infection but over-expressing hepcidin or following hepcidin peptide administration.
In contrast, skin conductance variability - mediated by intermittent palmar sweat release and reuptake - more directly mirrors ongoing sympathetic nerve activity to palmar sweat glands, as measured with neurography [ 5].
Partial or non-responses to conventional treatments for depression may be moderated or mediated by the presence of stressors such as losses, abuse, neglect, and ongoing conflicts and frustrations.
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