Sentence examples for mediated by microglia from inspiring English sources

1 In MS, the innate immune response is mainly mediated by microglia and circulating monocytes, recruited to MS inflammatory lesions.

Inflammatory response in the CNS mediated by microglia cells play an important role in host defense and is implicated in the pathology of neurodegenerative diseases.

A beneficial effect of apocynin on neurotoxic effects mediated by microglia has been shown in a mouse model of PD [ 40].

Disease exacerbation is associated with exaggerated CNS inflammatory responses to systemic inflammation mediated by microglia that become 'primed' by the underlying neurodegeneration.

Our data therefore reinforce the importance of the HCAR2 pathway in inflammation and also suggest its potential relevance for neuroinflammation mediated by microglia.

28 This was a study designed to investigate the central nervous system regulation of inflammation mediated by microglia and astrocytes, in which murine astrocyte cultures were treated with bacterial lipopolysaccharides.

The possibility of dendritic and synaptic damage mediated by microglia-derived glutamate was previously proposed as an underlying factor in Rett syndrome pathology [ 78].

Several studies have shown that brain inflammation accompanying injury is mainly mediated by resident microglia, and inflammatory responses are harmful to surrounding neurons due to the cytotoxicity of mediators, such as nitric oxide (NO) and TNF-α [1] [8].

A cascade of chemokines and cytokines mediated by activated microglia cells leads to cell death through decreased arborization of neurons.

Modulation of innate immunity by natural plant products may represent an attractive strategy to prevent inflammation associated with neuron dysfunction mediated by activated microglia [ 31].

In the brain, OS damage is mediated by the microglia, a macrophage-like, phagocytic cell that is normally inactive unless confronted by potentially damaging xenobiotics.