Sentence examples for mediated by methylation from inspiring English sources

Epigenetic modifications are mediated by methylation, deacetylation, ubiquitination, phosphorylation and microRNA.

In this regard, regulation of imprinted IGF2R expression is mediated by methylation of an intronic CpG island [ 30].

The direct effects of age on gene expression not supported to be mediated by methylation are also shown (direct beta, SE, p-value).

The method applied in the mediation package calculates the proportion of the association between tobacco smoking and expression that is mediated by methylation.

To verify whether the methyltransferase-dependent pathway was mediated by methylation of H3K79, we replaced histone H3 by a H3K79R mutant and grew strains at 37°C to partially suppress the URA3 silencing defect in this mutant [ 55].

In our data, almost all associations between air pollutants and lung function remained after adjustment for DNA methylation, which suggests that pulmonary effects of air pollutants were not mediated by methylation.

Furthermore, no correlation was noted between the methylation status and CTR1 expression, which is in line with previously reported data on decitabine showing that CTR1 expression was mediated by methylation-independent mechanisms [ 14].

They also showed that transcriptional silencing is mediated by both methylation and histone deacetylation, although the effect of methylation was dominant for gene silencing.

The gene-silencing pathway mediated by H3K27 methylation is linked to the second major silencing pathway (i.e., DNA methylation) via a deacetylase called SIRT 1 that is recruited by the PRC2 complex and contributes to gene silencing (Muntean and Hess 2009).

All together, these data suggest that transcriptional repression mediated by DNA methylation is a consequence of a cross-talk between methylated CpG density, MBD proteins and transactivators.

Curradi, M. et al. Molecular mechanisms of gene silencing mediated by DNA methylation.