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The ER → Golgi → PM concentration gradient of cholesterol in mammalian cells, and ergosterol in yeast, appears to be sustained by specific intracellular transport processes, which are mostly mediated by lipid transfer proteins (LTPs).
Transport through plasma membrane mediated by lipid membrane fusion can not be specifically detected by specific inhibitors, such, for instance, fusion inhibitors like nigericin.
These findings suggest that, in addition to endocytosis, lipoplexes may enter cell via a temperature-independent mechanism, which could be mediated by lipid mixing.
This supports the hypothesis that stress-induced injury is mediated by lipid peroxidation.
Spermatozoa are particularly sensitive to oxygen-induced damage mediated by lipid peroxidation [ 43, 44].
Previous research suggested that toxicity of MNPs was mediated by lipid peroxidation, ROS, and oxidative stress [ 15].
Similar(41)
The circular dichroism results show that conformational transitions are mediated by lipid-specific interactions in the case of LL7-27, unLL37 LL37.
The present study was designed to evaluate the differential vulnerability to oxidative stress mediated by lipids through a cross-regional comparative approach.
The identification of aldehydic adducts provides a molecular clue of chondrocyte matrix damage mediated by lipid-free radicals [ 26].
Therefore, the mechanisms of induction of protection mediated by lipids in this species may differ compared to humans [ 5, 20].
In the special type of programmed cell death that occurs when the top layer of cornified cells is formed [ 45, 46], the CE is retained and is actually the main structure conferring the barrier function (partly mediated by lipids).
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