Sentence examples for mediated by extensive from inspiring English sources

We hypothesize that acute and persistent infection of professional immune cells (T-cells, monocytes and macrophages) and non-immune cells (endothelial cells and smooth muscle cells) contributes to a sustained inflammatory response mediated by extensive cellular 'crosstalk' and numerous cytokines/chemokines.

Nonetheless, AMsh glia remodeling requires membrane growth and is therefore likely mediated by extensive changes in the glial cytoskeleton.

In the malaria parasite Plasmodium falciparum, immune evasion is mediated by extensive recombination among subtelomeric var gene paralogs (Kraemer et al. 2007; Kyes et al. 2007).

Histone-DNA interfaces are mediated by extensive direct and water-mediate hydrogen bonds, ionic interactions, nonpolar contacts, and the alignment of helix dipoles relative to phosphate backbone ions.

In NTDT, downregulation of hepcidin is mediated by extensive erythropoiesis as well as chronic anemia 38, hypoxia 38, as well as growth differentiation factor-15 (GDF-15) 39, 40 and twisted gastrulation factor 41.

Unlike canonical protease inhibitors that simply bind to the protease active site, inhibition by serpins requires mechanical deformation of the protease active site, mediated by extensive structural rearrangements and repacking of the serpin structure.

Substrate binding is mediated by an extensive network of H-bonds and van der Waals interactions.

Substrate binding is mediated by an extensive H-bond network and van der Waals interactions which sequester both the substrate and co-substrate.

Plant response to salinity is mediated by immediate and extensive reprogramming of the spatial and temporal gene transcription, instigated by the interaction of transcription factors with four major groups of CREs including ABA-independent CREs (CBF/DREB; NAC and ZF-HD) and ABA-dependent CREs (AREB/ABF; MYC/MYB) [ 42, 43], all of which were represented in TaHKT2 1 gene family.

Like all other SAM-dependent OMTs, SAM/SAH binding is mediated by means of an extensive network of hydrogen bonds and van der Waals interactions that sequester SAM and position its methyl group near tricetin hydroxyl groups.

Patterns of genetic diversity suggest extensive gene flow mediated by both males and females within the continuous boreal forest.