Sentence examples for mediated by exogenous from inspiring English sources

Anversa's work has led to the recognition that the heart is an organ permissive for myocardial regeneration, which can be mediated by exogenous progenitor cells, endogenous progenitor cells or both.

Our observation that in chick, motor neuron loss mediated by exogenous TDP-43 expression requires the integrity of the TDP-43 C-terminal section in addition to its N-terminally localized RNA-binding function could further point to the possibility that ALS/FTLD-linked C-terminal TDP-43 missense mutations may act through a pathway determined by inherent TDP-43 RNA-binding function.

Thus, motor neuron loss mediated by exogenous TDP-43 expression requires both, N-terminally localized inherent RNA-binding function, as well as the integrity of the C-terminal section suggesting the intriguing possibility that C-terminal TDP-43 missense mutations may act through a pathway determined by inherent TDP-43 RNA-binding function.

The level of oxidative stress mediated by exogenous sources or endogenously generated upon receptor stimulation regulates the sensitivity to Fas-mediated apoptosis [ 188].

In addition, compartmentalization of lipid classes (neutral lipid-NL) mediated by exogenous ABA (10 μM) based on the TLC plate analysis was explored (Additional file 1: Figure S1).

This could be the result of decreased ROS production or of improved ROS removal, but the ability of preconditioning to protect against oxidative stress mediated by exogenous hydrogen peroxide [155,156] argues in favour of the latter.

The role of Tat as an inhibitor of Dicer has been questioned and our results support and extend the conclusion that Tat does not inhibit RNAi that is mediated by either exogenous or endogenous miRNAs.

The diminished abundance of R1441C and D1994A LRRK2 in the absence of exogenous CHIP could be due to degradation mediated by endogenous CHIP, other degradation mechanisms or to other possible effects such as altered expression.

In the IFN-I induction pathway mediated by endogenous RIG-I like helicases, IRF3 lies downstream of MAVS, and exogenous expression of MAVS can lead to the phosphorylation and nuclear translocation of IRF3 [1].

This increase involved a regulatory mechanism mediated by RACK1 because exogenous increases in RACK1 led to increased BDNF expression, resulting in reduced ethanol consumption (McGough et al. 2004).

The lack of a similar effect on WC from fathers who smoked could again point towards an epigenetic effect on increased adult central fat distribution, mediated by exposure to exogenous free radicals in pregnancy resulted in changes such as DNA methylation.