Previous work from other groups already provided evidence that changes in gait during dual tasking are mediated by reduced executive functioning [ 18].
Moreover, regression analyses mainly show that increase in age-related deficit with level of specificity of AM is largely mediated by performance on executive functions (updating and inhibition) and to a lesser extent feature binding in working memory.
Finally, we considered that the relationship between metacognitive efficiency and age may be mediated by changes in executive function.
Generalizability is limited because we report findings from only one urban tertiary care hospital and because the EWR effect may be mediated by the individual executives of this hospital.
These effects may be mediated by PFC cerebellum contributions to executive processing.
The positive association we report here between DLPFC activity and CBT responsiveness may be mediated by facilitation of effective CBT by executive processes modulated by the DLPFC.
Dopaminergic neurons originate in the ventral tegmental area (VTA) and substantia nigra compacta (SNc), and projections to areas including the prefrontal cortex [12], integrate reward circuitry with executive functions mediated by the frontal cortex.
By injecting tracer into the prefrontal cortex, we focus on the limbic cortical-ventral striatopallidal circuitry that has been implicated in a number of psychiatric disorders that are thought to involve changes in reward and executive functions mediated by the prefrontal cortex (PFC), including addiction [26], [27], [28], [29], [30], [31], [32].
It is important to note that executive functions, mediated by frontal regions, rather than memory, showed greater potential response to ChEI in this cohort.
A number of studies have shown that AUD is associated with structural and functional abnormalities in the prefrontal cortex (Goldstein et al. 2004; Volkow et al. 1994), along with neuropsychological impairments in a variety of executive functions mediated by the prefrontal cortex (Sullivan et al. 1993, 1997).
