Risks for cancers mediated by such errors should then greatly increase.
Thus, consistent with predictive coding models of perception, associative learning is mediated by prediction-error dependent changes in connectivity.
These mutations are mediated by an error-prone DNA polymerase, DNA polymerase IV, which is regulated by RpoS, the stress response sigma factor [ 29], the heat-shock chaperone GroES [ 29], and polyphosphate kinase [ 30].
This suggests that neuronal signalling of predictions is mediated by alpha and prediction errors by gamma.
Alternatively, it has been proposed that mtDNA mutations are principally induced by replication errors mediated by mtDNA polymerase Y (Zheng et al., 2006).
Third, we should also consider that some of the detected heterogeneities were mediated by variance in measurement errors and not by variance in a biological predictor.
It accounts for a learning-dependent contribution from CS+ responses in auditory cortex to visual cortex responses that depends on whether the visual stimulus was present or not (c.f., a prediction error mediated by top-down signals from auditory areas).
In particular, with a procedure to elicit errors in the SST, we examined whether error and non-error control were mediated by the same pathways.
It is therefore generally assumed that the suppression of prediction error units is mediated by inhibitory interneurons (whose intrinsic connections are confined to each hierarchical level).
Our simulation studies suggest that our proposed approach returns reasonably unbiased estimates of the direct effect, i.e. the effect not mediated by cell type, and reasonable standard error estimates.
