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It is now well established that stage-specific regulation of gene expression in Leishmania is predominantly mediated by elements in the 3'UTR of mRNAs (reviewed in [ 22, 23]).
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As some tolerance was also noted to third generation cephalosporins (Tables 1 and 2), it is suggested that this be investigated further to determine if this tolerance was mediated by transferable elements as transfer of these elements could be of clinical significance.
Intra- and interchromosomal duplications are often mediated by Ty elements, but also occur in the absence of repeated elements, as a result of microhomology/microsatellite-induced replication (MMiR).
Our findings characterize REP elements as hot spots for transposition and reinforce the relationship between REP sequences and genomic plasticity mediated by mobile elements.
Genomic rearrangement mediated by IS elements has been observed in Hbt. salinarum [6].
This high occurrence of transposases suggests that pRF genes have been frequently rearranged through recombination mediated by tnp elements.
Indeed, it is possible that the majority of Alu-associated deletions are mediated by Alu elements through repair processes initiated by double-strand breaks, rather than through the process of NAHR.
Differences between B. pertussis isolates are mainly due to mutations in structural genes encoding toxins and adhesins, differential expression of genes such as those encoding fimbrial proteins, and gene reduction mostly mediated by IS elements [4] [7].
However, this technique encounters significant limitations in more complex networks where the relationship between a pair of neurons (or electrodes) can be mediated by other elements, which is a much more common scenario.
This is in large part thanks to lateral gene transfer mediated by mobile elements [ 60].
Prokaryotic transcriptomes change not only in response to physiological parameters but also to genetic rearrangements mediated by mobile elements.
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