Sentence examples for mediated by down from inspiring English sources
From previous studies it is evident that reduction of phytate mediated by down regulation of MIPS might result in abortion of seeds (Nunes et al. 2006) or aberrant embryo structure (Kuwano et al. 2009) which may lead to impaired germination of the transgenic seeds.
This is mediated by down- or up-regulation of genes that are usually correlated to the mechanism of action of the individual chemotherapeutic agent or relevant resistance mechanisms.
TGFβ regulates cell proliferation positively or negatively, mediated by down- or upregulation of the cyclin-dependent kinase inhibitor p21 (also known as Waf1), respectively (Miyazaki et al., 1998).
Furthermore, they showed inhibition in growth and cancerous properties including colony forming efficacy, migration and invasion that were mediated by down regulation of MMP-2, MMP-9, VEGF and hnRNP-K proteins.
DOI: http://dx.doi.org/10.7554/eLife.01888.010 To examine whether the anti-inflammatory effects of blocking TSLP were mediated by down-regulating epidermal expression of inflammatory mediators, we measured expression of representative type 1 and type 2 cytokines.
These results suggest that stabilization of TNF-α mRNA by Btk is mediated by down-regulation of TTP.
The increased cell motility mediated by down-regulation was S1PL was pertussis toxin sensitive suggesting "inside-out" signaling of intracellularly generated S1P.
Therefore, it is possible that the alterations of morphology and sarcomere assembly that we observe in myotubes expressing ectopic miR-221 and miR-222 are mediated by down-modulation of cell cycle-independent functions of p27 and/or by inhibition of other targets.
They further propose that this effect of miR-519 is partly mediated by down-modulating HuR levels.
These results suggest that ameliorated AD symptoms by GCSE treatment is mediated by down-regulation of pathogenic cytokines.
Our data demonstrate that a substantial part of the increase in LPL activity in BAT during prolonged cold exposure is mediated by down-regulation of ANGPTL4.
