Figure 1 shows schematically how DA couplings (mediated by direct contact, intervening atoms, or water) fluctuate with geometry, modulating HDA.
There are many models of cellular interaction mediated by direct contact (tunneling nanotubes, synapses, trogocytosis) or microparticle mediation to 1(f)).
Farsad, K. et al. Generation of high curvature membranes mediated by direct endophilin bilayer interactions.
Therefore, impaired LC3 lipidation by H2O2 was likely mediated by direct inhibition of the autophagy pathway.
Unconventional secretion of FGF2 from cells is mediated by direct protein translocation across the plasma membrane.
The effects of ecosystem engineers can be mediated by direct and indirect interactions.
It is currently not clear whether CNOT2 (or CNOT1 and CNOT3) are associated with the DNA or chromatin and whether this is mediated by direct or indirect effects.
We show here, using photoaffinity and fluorescent derivatives, that this inhibitory effect is mediated by direct binding of cyclopamine to the heptahelical bundle of Smoothened (Smo).
The experiments confirmed that the retinal damage is not mediated by direct effect of the alkali, which is effectively buffered by the anterior segment.
While conducting downstream targeting studies, we found that the tumor-promoting function of miR-4516, in part, was mediated by direct targeting of PTPN14 (protein tyrosine phosphatase, non-receptor type 14) which, in turn, regulated the Hippo pathway in GBM.
HNF-4 and ARP-1 bind with similar affinities to the C3P site, suggesting that their opposing transcriptional effects may be mediated by direct competition for DNA binding.
