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The metamorphosis processes involve tissue differentiation mediated by differential gene expression and protein synthesis [20] [23].
These effects were mediated by differential phosphorylation of IRF3, IRF7, IKKα/β and c-Jun.
The disrupted RNA editing was found to be mediated by differential expression of ADARs in HCC (Chan et al., 2013).
Experiments in zebrafish showed that the cell sorting between odd- and even-rhombomeres is mediated by differential expression of Eph receptors and ephrins [15].
Metamorphosis entails the reorganization of existing tissues and construction of new tissues, with biochemical and physiological changes mediated by differential gene and protein expressions [20] [23].
In particular, one hypothesis is that the shifting temporal dynamics of cognitive control region activation across the Money (sustained) and Liquid (transient) conditions might be mediated by differential sustained activity in subcortical reward regions.
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On the other hand, the enhanced excitability in Tg20 and Prnp −/− mice can be mediated by the differential expression of specific glutamate or GABAA subunit receptors.
Thus, the diversity of clonal T cell proliferation is mediated by the differential expression of CTLA-4 on the cell surface of activated individual T lymphocytes.
In addition, variations in mucin glycosylation patterns can cause changes in tumour cell adhesion, migration and invasion (Casey et al, 2003), and can be mediated by the differential expression of glycosylation enzymes including fucosyltransferases and sialyltransferases.
The effects of the APOE genotype on the increased risk of Alzheimer's disease are likely to be mediated by the differential effects of apoE4 on amyloid- β accumulation in the brain [ 22, 23].
To our knowledge, this is the first time that miRNA gene regulation has been shown to be mediated by both differential miRNA expression and miRNA-targeting-specific promoter methylation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com