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In any case, based on the present findings it can be suggested that the observed strain differences in (non)adaptive anxiety behaviour are at least partly mediated by differences in GABAergic and mGluR5 mediated transmission.
Since the Hong Kong virus differed from its antecedent Asian virus by its HA antigen, but had retained the same (N2) NA antigen (16 ), researchers speculated that its more sporadic and variable impact in different regions of the world were mediated by differences in prior N2 immunity (16 – 16 ).
They also show that vascular and lymphatic endothelium have different set points, that this difference is mediated by differences in expression of VEGFR3, and provide evidence that this pathway controls artery remodeling in vivo.
Since both IDC and ILC are believed to start in the terminal duct lobular unit (TDLU) of the breast [ 1, 2], and these normal cell populations showed similar gene expression profiles, it is likely that the different morphological appearances of the two tumor types are mediated by differences in their mechanisms of carcinogenesis.
In summary, Nicotiana spp. showed highly-specific induced JA accumulation in response to different HAEs due to their different elicitor compositions and we hypothesize that this may be mediated by differences in receptor-ligand interactions amongst the species.
This association was only partially mediated by differences in BMI.
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One final caveat in this study is that chorionicity data were not available on these twins, a potential limitation given that whether or not MZ twins share a placenta may influence epigenomic and transcriptional differences mediated by subtle differences in the prenatal environment [ 58].
The lower metabolism of the core relative to the shell provides an opportunity to look at phenotypic profile differences mediated by the difference in metabolism.
Differences among villages, possibly mediated by subtle differences in wealth and dietary habits within this generally homogeneous environment, was significant for intakes of vitamin B-12 (P = 0.0023) and betaine (P = 0.0024) and for plasma concentrations of choline (P value= 0.0039), folate (P = 0.0131), methionine (P = 0.0022) and the SAM/SAH ratio (P = 0.0038).
Perhaps this cancer difference by country of origins for US Hispanics is mediated by genomic differences representing distinct proportions of admixed heritage.
However, phenotypic sexual dimorphism may also be mediated by sex differences in gene expression when a key transcript differs in abundance between males and females.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com