Sentence examples for mediated by defective from inspiring English sources

Additional signalling defects mediated by defective formation of cilia may also play a role.

The internal genomic deletions described here are the most extensive defects observed in DENV and may be part of a much broader disease attenuating process that is mediated by defective viruses.

β-Cell lipid accumulation is mediated by defective intracellular lipid oxidation associated with leptin resistance (4).

Regardless, our findings support the idea that possible gastrulation failure observed in CD98hcΔ/Δ embryos is not mediated by defective integrin β1 function but rather due to the loss of other functions involving an intact extracellular domain of CD98hc.

We propose that this effect is mediated by the defective centrosomal recruitment of proteins at the onset of mitosis.

Downregulation of Dpy19l1 mediated by shRNA resulted in defective radial migration of glutamatergic neurons in vivo, which was restored by the expression of shRNA-insensitive Dpy19l1.

The radiation-induced phosphorylation of p53 protein at serine 15, largely mediated by ATM kinase, was defective in AT, A -T) A -Tin 2/4 heterozygous candinrs, while the G1 cell cycle checkpoint was disrupted in all AT and A(-T) cases, and in 3/10 AT heterozygotes.

The defective neurogenesis is mediated by non-cell-autonomous mechanisms involving proinflammatory changes.

This provides genetic evidence that the increased sensitivity to UV by transcription inhibition observed in wild type and NER defective cells is mediated by HR.

Defective MTX uptake mediated by the RFC is a common mechanism for drug resistance in many tissue types, including ALL, osteosarcoma, and non-Hodgkin's lymphoma [ 32].

The pleiotropic effects of c-Myc on tumorigenesis are thought to be mediated by its target genes, because transcriptionally defective Myc alleles have diminished transforming potential [ 11].