Sentence examples for mediated by complement from inspiring English sources
The GTKO NPI recipients have improved rates of normoglycemia, likely due to decreased susceptibility of xenografts to innate immunity mediated by complement and preformed xenoantibody.
Neurologic symptoms are mediated by complement binding anti-ganglioside antibodies [2].
In conclusion, AdCAGsCD59-conditioned media conferred a significant (34.08±6.40%, p<0.01) protection against cell lysis mediated by complement in NHS.
Binding and phagocytosis of myelin by macrophages is mediated by complement receptor 3 (CD11b/CD18/CD18), a member of integrin family [12], [13].
She responded to eculizumab, suggesting that her MAHA was mediated by complement activation.
These data illustrate the lack of significant cytotoxicity mediated by complement proteins in the absence of effector cells.
20 In addition, possibilities of LGR5 targeted antibody-based therapy mediated by complement-dependent cytotoxicity in vitro, and an antitumor effect in a xenograft model has been demonstrated.
The alpha subunit of the eighth complement component (C8) is a single-chain plasma glycoprotein which functions in the cytolytic process mediated by the complement system through a sequence of polymerization reactions with other terminal components.
4– 7 In animal models, ofatumumab induced selective and prolonged B-cell depletion primarily mediated by effective complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity.
14, 20 It does not induce T- or B-cell depletion mediated by CDC (complement-dependent cytotoxicity), ADCC (antibody-dependent cell-mediated cytotoxicity), or apoptosis.
Namely they produce autoantibodies that can cause renal damage via disruption of cellular functions, cytotoxicity mediated by interactions with complement and release of inflammatory mediators.
