Sentence examples for mediated by classical from inspiring English sources

Muscle cells are, in fact, more capable than motor neurons to handle misfolded proteins, suggesting that mutant SOD1 toxicity in muscle is not mediated by classical mechanisms of intracellular misfolded proteins accumulation.

Thus, treatment with GP61-IFA induced a non-responsiveness that was rather complete and not mediated by "classical" anergy.

We suggested previously that the lexico-semantic repetition effects seen in secondary visual regions during bilingual language processing may be related to a more perceptual semantic system, compared to the abstract system that is mediated by classical language regions [13].

Non-image related responses to light, such as the synchronization of circadian rhythms to the day/night cycle, are mediated by classical rod/cone photoreceptors and by a small subset of retinal ganglion cells that are intrinsically photosensitive, expressing the photopigment, melanopsin.

We confirmed that nucleocytoplasmic translocation of Cdc5 is mediated by classical nuclear import machinery, because nuclear import of Cdc5 was completely lost in mutants of karyopherin (Kap) complex (srp1 and kap95 for Kapα and Kapβ mutants, respectively)[28], and of the nuclear pore complex (nup1)[29] (Figure S2A).

Importantly, not all actions of androgens upon the liver may be mediated by classical AR signaling.

In the present study we found that Cd-induced growth in ht-UtLM cells and ht-UtSMCs was not mediated by a classical ER mechanism of receptor binding and ERE-mediated gene activation, but through nongenomic pathways involving differential activation of growth factor receptors and subsequent MAPK/ERK1/2 phosphorylation.

The muscarinic influence on proliferation is, at least in part, mediated by the "classical" signalling pathways for muscarinic receptors, the inositol-phospholipid signalling cascade [42] involving two second messengers, diacylglycerol and inositol 1,4,5-trisphosphate (IP3).

Not all effects of BPA are mediated by the classical nuclear ERs (α and β).

This modulation is mediated by the classical MAP kinase cascades via Erk1/2 [ 99].

At later time points, however, the effects of oestradiol appear to be mediated by the classical ER pathway.