Sentence examples for mediated by binding from inspiring English sources

Currently, it is unknown whether the neuroprotective effects of oestrogen treatments in EAE are directly mediated by binding oestrogen receptors on neurons or are indirectly mediated by binding oestrogen receptors on non-neuronal CNS cells.

We conclude that UBX proteins are transcriptional repressors and activators, and that their actions are mediated by binding to promoter region sequences.

These results suggest that the regulatory activities of Ubx are direct and are mediated by binding of Ubx proteins to promoter region sequences.

The interaction with lipids and calcium activators is mediated by binding to the regulatory domains C1 and C2.

Structurally, this interaction is mediated by binding of the α-helical BH3 region of the proapoptotic proteins to a conserved hydrophobic groove on the prosurvival proteins.

Bioaccumulation is usually mediated by binding of metal ions by intracellular compounds, methylation, intracellular precipitation and other mechanisms.

Subsequent studies provided a structural basis for selective m6A binding (14) and showed that the destabilizing effect of m6A is mediated by binding to a family member, YTHDF2 (15).

In peripheral tissues thyroid hormone effects are mediated by binding to specific nuclear thyroid receptors, TRα and TRβ.

The entry of TcdA and TcdB into the target cell is mediated by binding to their receptors which triggers endocytosis.

The biological functions of chemokines are mediated by binding to cell surface chemokine receptors, which belong to the superfamily of G-protein-coupled receptors (GPCRs) [29].

MicroRNAs are well known regulators of protein expression and their action is mediated by binding to the 3'-UTR of target mRNAs.