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Instead, this part is focused on systemic benefits of n-3 PUFA mediated by AT.
There is considerable crosstalk between AT and a wide array of organs, underscoring the difficulty in dissecting tissue-specific effects of n-3 PUFA and additional benefits mediated by AT.
The observed neuroprotective effects of GDNF might be mediated by at least four different mechanisms: (i) reduction in NMDA-mediated calcium currents, (ii) upregulation of antiapoptotic gene expression, (iii) suppression of free radical production and/or (iv) increase in neuronal metabolic activity.
We found that p42 MAPK inactivation is mediated by at least two distinct phosphatases, an unidentified tyrosine phosphatase and a protein phosphatase 2A-like threonine phosphatase.
suggested that the oxidation of 5-epi-aristolochene to capsidiol was mediated by at least one elicitor-inducible cytochrome P450 hydroxylase.
Uptake of UA by primary renal proximal tubule epithelial cells (PTEC) of the rabbit inhibited in vitro cell proliferation that was mediated by at least two signaling mechanisms[143].
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For example, recurrent translocations can be mediated by AT-rich palindromic repeats [ 6- 8].
The major physiological activities of angiotensin II are mediated by AT-1 receptors.
Furthermore, the constitutive activation of Akt blocked the Mcl-1 downregulation, Bad dephosphorylation, and Bax translocation mediated by AT-101.
Knocking down ROCK1 also blocked PTEN activity, Akt inactivation, Mcl-1 downregulation, Bad dephosphorylation, and Bax translocation mediated by AT-101.
Inhibiting ROCK1 activation by both Y27632 and a ROCK1-specific siRNA attenuated the apoptosis mediated by AT-101 by inhibiting PTEN activity and Akt inactivation.
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