Sentence examples for mediated by altered from inspiring English sources

Inactivation and eventual elimination of duplicated genes can be mediated by altered epigenetic regulation, deletions, TE insertions, and/or point mutations causing premature stop codons.

We did not observe such differences, however, suggesting that the KLK3-prostate cancer association is not mediated by altered PSA levels.

Genetic analysis suggests that many of the axon phenotypes observed in ju89 mutants are likely mediated by altered or reduced function of microtubules composed of TBA-1 and TBB-2 subunits.

Thus, since n-3 LCPUFA intervention reduces n-6-LCPUFA and their metabolites, such as PGE2 [ 6, 23, 44], changes in T levels may be mediated by altered CYP19A1 levels.

Ischemia reduces the isomerization from A-M.ADP.Pi to AM*.ADP.Pi, altering the kinetics of crossbridge activation through a mechanism that may be mediated by altered TnT and TnI phosphorylation.

Those changes may be mediated by altered expression of NMDAR subunits and sonic hedgehog.

Thus, the relatively modest changes in p16 mediated by altering miR-24 levels are likely insufficient to recapitulate the influence of p16 changes occurring during senescence.

NGF also increases the expression of GABAergic terminals in cultured hippocampal neurons, an effect mediated by altering Hes1 expression [ 13].

Synaptic plasticity is in part mediated by altering the number of synaptic AMPA receptors through fast trafficking mechanisms [ 121].

We found that this effect was mediated by altering the uterine resting membrane potential and action potential.

These observations have potential implications on the role of DNA methylation on regulating gene expression, a phenomenon likely mediated by altering the methylation status of enhancers and other regulatory elements.