mediated by accumulation

USAGE SUMMARY

The phrase "mediated by accumulation" is correct and usable in written English.
You can use this phrase when you want to describe a situation wherein an accumulation of something (such as wealth, knowledge, or power) leads to some sort of mediation. For example: "The success of the negotiations was mediated by the accumulation of political influence."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

7 human-written examples

The pathophysiological effects of ALDH2 polymorphism may be mediated by accumulation of acetaldehyde and other reactive aldehydes.

Pharmacology & Therapeutics

These data imply that pemetrexed-induced genomic instability is mediated by accumulation rather than removal of uracil.

Cell Death and Disease

We should also be cautious about drawing too close a parallel between synapse degeneration in Wallerian degeneration and degeneration mediated by accumulation of an extracellular misfolded protein.

ASN Neuro

It is currently considered that increased Nrf2 transactivational activity is mediated by accumulation of Nrf2 protein in the cell cytosol with CK2-driven entry of Nrf2 into the nucleus and increased ARE-linked gene transcription.

Antioxidants and Redox Signaling

The expansion of CPCs is at least in part mediated by accumulation of the Wnt signaling effector β-catenin that are negatively regulated by membrane Notch (Kwon et al., 2011).

eLife

The repressive histone modifications observed in the regulation of Kcnq1 and Igf2r imprinted gene clusters in mouse placenta are mediated by accumulation of lnc-RNAs near the target promoters [ 41].

BioMed Research International

Human-verified similar examples from authoritative sources

Similar Expressions

53 human-written examples

Taken together, the down-regulation of miR-15b, miR-16, miR-20a, and miR-20b in CNE cells might be mediated by the accumulation of p53 or the stabilization of HIF-1α during hypoxia.

Plosone

A second key finding is that the cell death mediated by the accumulation of LAPTM5 protein in NB cells is a lysosomal cell death with the typical features of lysosomal destabilization through LMP and with the impaired autophagy in a caspase-independent manner, as a molecular mechanism for spontaneous regression of NB tumors.

Plosone

These data suggested that hSKP senescence was mainly mediated by intracellular accumulation of p16.

Aging Cell

Hypoxia-stimulated proteasomal degradation of HMGR is mediated by the accumulation of sterols in the mevalonate pathway.

Cell Death and Disease

This suggests the existence of a positive regulation mechanism by small G proteins on plant resistance mediated by H2O2 accumulation [ 39, 51, 65].

BMC Plant Biology

Expert writing Tips

Best practice

When using "mediated by accumulation", ensure that the subject and object of the sentence clearly define what is being mediated and what is accumulating. This enhances clarity and avoids ambiguity.

Common error

Avoid using "mediated by accumulation" in overly complex sentences where it can become convoluted. Break down long sentences into simpler ones for better readability.

Linguistic Context

The phrase "mediated by accumulation" functions as a passive construction, indicating that a process or outcome is influenced or brought about by the gradual increase or buildup of a particular substance or factor. As Ludwig AI confirms, it is correct and usable in written English.

Expression frequency: Uncommon

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Encyclopedias

0%

Ludwig's WRAP-UP

In summary, the phrase "mediated by accumulation" is a grammatically sound construction primarily employed in scientific and technical writing to elucidate causal relationships where a buildup or aggregation influences an outcome. As Ludwig AI points out, it is indeed correct and usable in written English. The phrase functions passively, emphasizing the role of accumulation in facilitating a process. Alternatives such as "caused by accumulation" or "induced by accumulation" can be considered depending on the nuances desired. When using this phrase, clarity is key; ensure that the subject and object are well-defined to avoid ambiguity. While the phrase is accurate, overuse in complex sentences should be avoided for better readability.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

caused by accumulation

Indicates direct causation from the buildup, similar to 'mediated by' but more direct.

induced by accumulation

Emphasizes the triggering effect of the accumulation, suggesting a reaction.

triggered by accumulation

Highlights accumulation as the event that initiates a process.

brought about by accumulation

Similar to "mediated by", but focuses on the result of the accumulation.

influenced by accumulation

Indicates a less direct effect where accumulation affects a certain process or event.

driven by accumulation

Suggests that the accumulation is the primary force behind a particular outcome.

stemming from accumulation

Highlights the origin of something as being accumulation.

arising from accumulation

Similar to 'stemming from', indicating origin or source.

resulting from accumulation

Highlights the accumulation as the reason behind a specific result.

dependent on accumulation

Indicates that the effect cannot occur without the accumulation.

FAQs

How can I use "mediated by accumulation" in a sentence?

Use "mediated by accumulation" to describe processes or effects that occur due to a buildup of something. For example: "The inflammatory response is mediated by the accumulation of cytokines".

What are some alternatives to "mediated by accumulation"?

Alternatives include "caused by accumulation", "induced by accumulation", or "triggered by accumulation", depending on the specific context.

Is "mediated by accumulation" grammatically correct?

Yes, "mediated by accumulation" is grammatically correct and commonly used in scientific and technical writing.

What does "mediated by accumulation" mean?

It means that a particular process or effect is brought about or influenced by the buildup or gathering of a specific substance or factor.