Sentence examples for mediated by abnormalities from inspiring English sources

A few researchers have hypothesized that insulin resistance in adipose tissue could be mediated by abnormalities in thyroid hormone receptor signaling pathways and gene regulation.

15 These symptoms appear in the early stages of the disease, advancing independently with disease duration, and are mediated by abnormalities of the frontal lobe or frontal subcortical connections.

Myelin instability, potentially mediated by abnormalities of ABCA8 lipid transporter expression, may be an important precursor to α-syn pathology in MSA, consistent with the unique oligodendrocyte focus of the disease.

The prevailing view has been that injury and inflammation result in AVD, but there is increasing evidence that the cell-ECM changes that characterize AVD are mediated by abnormalities in molecular programs that regulate cardiac development (Markwald et al., 2010; Hinton and Yutzey, 2011).

For instance, EGFR-targeted inhibitors could be coupled with inhibitors of KRAS, MET, PI3K, IKK, HER2, HER3, or even with inhibitors of HER2/HER3 dimerization, to anticipate resistance mediated by genetic abnormalities in members of these downstream or parallel pathways.

Studies have further shown that Q waves carry an increased risk for impaired functional status and all-cause mortality, effects which both appear to be mediated by structural abnormalities suggestive of global rather than regional cardiac dysfunction [ 9].

These results indicate that visuospatial and numerical disabilities are interlinked and may be mediated by an abnormality in constructing a mental number line and representing ordinal numbers.

The associations between cystic lesions and knee symptoms were further adjusted for effusion or cartilage defects/BMLs to see if they were mediated by these structural abnormalities.

TNFα system is probably important in determining cholesterol levels in lean subjects, while in obese this effect might be mediated by other metabolic abnormalities.

To test the hypothesis that the impact of postnatal sepsis/necrotizing enterocolitis (NEC) on neurodevelopment may be mediated by white matter abnormality (WMA), which can be demonstrated with magnetic resonance imaging (MRI).

Thus, we speculated that profilin-1 functions as an ultimate and common cellular channel in endothelial abnormalities mediated by AGEs.