Sentence examples for mediated breakdown from inspiring English sources
In this paper, we describe the synthesis of a series of novel peptidomimetic glutathione analogues that are stabilized against peptidase mediated breakdown.
This paper describes a biosensing concept for exotoxins secreted by Staphylococcus aureus and Pseudomonas aeruginosa based on the toxin mediated breakdown and subsequent fluorescent dye release from phospholipid vesicles (liposomes).
The union of the hydroxamic acid zinc-chelator with a urea isostere for the glu cys amide bond led to a glutathione analog which retained inhibitory potency toward glyoxalase-I while possessing resistance toward γ-glutamyltranspeptidase mediated breakdown.
Apparently, the intracellular stability of the injected ExoS54-Cre is much shorter than the required 20 hours, presumably due to proteasome mediated breakdown.
25 mM theophylline was added to the incubation bath in order to inhibit phosphodiesterase mediated breakdown of cAMP.
By inhibiting PDE4-mediated breakdown of cAMP, apremilast works intracellularly to regulate inflammatory mediators that are considered to play an important role in the pathogenesis of psoriasis and PsA [ 175, 176].
Heparin inhibited the plasmin-mediated breakdown of the VEGF165 isoform (Figure 3F), but not VEGF121 (Figure 3G).
The respiratory distress of critically ill anthrax patients might be caused by LT-mediated breakdown of the respiratory barrier and influx of fluid into the lungs.
However, as Mdm2 induces ubiquitin-mediated breakdown of target proteins we first analyzed whether Mdm2 could catalyze ubiquitin addition to FOXO4 in vitro.
Again this is consistent with the observed lack of poly-ubiquitination and suggests that either FOXO4 is degraded through another pathway for example caspase-mediated breakdown, or alternatively, that (multiple) mono-ubiquitinated FOXO4 is targeted to a cellular compartment for example PML bodies from which it is not efficiently extracted.
Muscle atrophy during cachexic states ultimately stems from ubiquitin-mediated breakdown of myofibrils.
