Sentence examples for mediated both by from inspiring English sources

One possible explanation is that the dose/response curve for leptin is intrinsically bathtub-shaped, with adverse effects mediated both by excess and by insufficient leptin stimulation.

This inhibition of the Rho kinase signaling pathway may be sufficient to inhibit PRBC-mediated HLEC apoptosis mediated both by cytoadherence and by diffusible factors, assuming that Rhokinase is activated by both stimuli.

In 1995, Gaubatz et al. [ 28] showed that AP2 acts as an inhibitor of Myc-mediated transactivation, a function that is mediated both by competition of AP2 with binding of Myc or Max and by direct protein-protein interaction of AP2 with the BR/HLH/LZ domain of the Myc protein.

These elevations seemed to be mediated both by the lack of monitoring of chronically infected cows and by an elevated incidence of intramammary infections.

The continuity in aggressive antisocial behavior symptoms from childhood to adolescence was largely mediated by genetic influences, whereas continuity in nonaggressive antisocial behavior was mediated both by the shared environment and genetic influences.

Interestingly, Fasudil inhibited EC apoptosis mediated both by cell-cell contact and by soluble factors but did not affect PRBC cytoadherence.

In the closed conformation, ion coordination is mediated by both MIDAS serines, by the second MIDAS aspartate, and by three water molecules.

Liu, H., Wang, P., Song, W. & Sun, X. Degradation of regulator of calcineurin 1 (RCAN1) is mediated by both chaperone-mediated autophagy and ubiquitin proteasome pathways.

The microtubule destabilizing activity is regulated by phosphorylation, mediated by both growth factor stimulated- and cell-cycle regulating kinases.

This cytotoxicity is facilitated by GSH depletion mediated by both GST-M1 through conjugation and MRP1 through efflux.

The phosphorylation is mediated by both growth factor receptors and by the non-receptor tyrosine kinase, Src [ 8, 17, 18].