Fundamentally, technology creates a mediated and low-resolution approximation of life that does offer utilitarian benefits and some entertainment value.
Indeed, we found that MRP1 was highly expressed in SKOV3 and HEY cells (highly resistant to As2O3 mediated effects) and low in T80 cells.
Binding, uptake and fusion by target cells are believed to involve clathrin-mediated and low-pH-induced endocytosis [ 14].
At the other extreme of the leprosy spectrum, tuberculoid (TT) patients present strong M. leprae-specific cell-mediated immunity and low or absent antibody production, such that patients present with low BI.
Although a direct link between pathogen-mediated population decline and low MHC variation has been difficult to demonstrate in natural populations [ 17], several studies have reported decreased pathogen resistance among MHC homozygotes (reviewed in [ 5]).
To verify the involvement of HDACs in Bcl11b-mediated cell cycle control and low sensitivity to genotoxic stress we applied the histone deacetylase inhibitor trichostatin A (TSA).
We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride.
Certain characteristics of PLAP, like cell surface localization [ 12], clathrin mediated endocytosis [ 13] and low shedding into circulation makes it an ideal target for immunolocalization and immunotherapy [ 14].
At the other, lepromatous leprosy (LL) is a progressively disseminating disease characterized by extensive bacterial multiplication within host cells and low cell-mediated immunity (CMI) to the pathogen.
We show transfection efficacy of >60% and low biomaterial-mediated cytotoxicity in primary human BTICs in vitro even when the BTICs are grown as 3-D oncospheres.
Acidic residues in the membrane-proximal stalk region of B5 are required for GAG-triggered EV disruption (Roberts et al, 2009), and it is possible that both GAG- and low pH-mediated EV rupture share a mechanism that depends on B5 and A34.
