Sentence examples for mediated alteration from inspiring English sources

Our results suggest a previously unknown mechanistic basis linking transcriptional dysregulation to cell death in neurodegeneration through TBP mediated alteration of Vdac1 expression.

Such an hαSyn mediated alteration of VMAT/CAT-1 GFP distribution further deVMAT/CAT-1 GFPAT/CAT-1::GFP fluorescence of distributionites was only located in discrete punctate spots without visible lines in L4 worms (further4I–M), which was prior to the obvious start of developedeuron degenerandon in this worm VMAT/CAT-1 GFP

Considering the crucial role of PDGF signaling in pulmonary vascular remodeling [8], [9], the increased presence of growth factors signaling in human and experimental PAH [8], [10], [13] and PDGF and FCS mediated alteration of GSK3ß activity, collectively suggests GSK3ß plays an important role in the pathogenesis of PAH.

We found that the decreased cell proliferation and survival induced by N-cadherin overexpression was abrogated by N-cadherin blockade, which reverses N-cadherin-LRP5 interaction in osteoblasts [39] and was partly restored by Wnt3a, indicating that N-cadherin-LRP5 mediated alteration of canonical Wnt signalling contributes to the negative effect of N-cadherin on cell growth.

HIV mediated alteration in B cell development and differentiation may result in loss of switched and non-switched memory B cells.

Chemically mediated alteration of expression of Stra8 (stimulated by retinoic acid gene 8) differentially affects the timing of meiosis in the ovary and testes and could influence sex.

In some species these changes are long-term, hormonally mediated alterations of coloration and frequently include a proliferation of the carotenoid (red and yellow) pigments.

These could possibly determine TNFα mediated alterations mainly the phenotypes of hepatic steatosis and fatty liver associated with several hepatic pathological states.

How these individual effects on IS organization are mediated by Nef, whether they represent independent or interconnected activities and how they each contribute to Nef mediated alterations in IS function, however remained unclear.

A single dose of an unselective beta-blocker abolished the HR differences between these genotypes, thus indicating that the studied differences involve central nervous system mediated alterations of heart rate and blood pressure.

Here we use a combination of Nef mutagenesis and pharmacological inhibition to analyze the relative contribution of these effects to Nef mediated alterations of IS organization and function on TCR stimulatory surfaces.