Sentence examples for mediated aggregation of from inspiring English sources

Also, because we use the same antibody (separately labeled by donor or acceptor fluorophores) against DR1, we neither induce large-scale antibody mediated aggregation of DR1 nor generate false FRET signals, since each DR1 molecule can be bound only by one antibody molecule.

Whether metallic ion mediated aggregation of antibody occurs in vivo is not known, but the present results suggest that similar clustering mechanisms could occur when hu3S193 binds to Ley on cells, particularly given the high surface densities of antigen on the target tumor cells.

Cu-mediated aggregation of Aβ leads to the formation of copper-bound, SDS-insoluble Aβ aggregates, that are neurotoxic due to the ability of Aβ-bound copper to undergo redox reactions at the cell membrane to generate reactive oxygen species [9], [10].

Our live-cell microscopy data also suggest that tryptophan-mediated aggregation of SOD1 is kinetically advantaged over aggregation that does not utilize tryptophan, reminiscent of kinetic factors operant in strain selection of infectious prions in vivo51.

We also investigated whether Zn7MT-2A can prevent the Cu-mediated aggregation of Aβ1 42.

Thus, polyQ-mediated aggregation of one Q/N-rich protein can convert another Q/N-rich protein from the soluble to the amyloidogenic state.

This indicates that the rate of polyQ-mediated aggregation of target proteins correlates with the rate of de novo appearance of ADE+ colonies.

The use of such metal-chelating drugs might not only reduce metal-mediated aggregation of Aβ, but also limit the formation of Cu II -Aβ and thus prevent the generation of oxidative stress and subsequent neurotoxiCu II -Aβ

Here, by using the androgen-independent LNCaP cell line, we present for the first time evidence that the antibody-mediated aggregation of PSMA greatly induce the basal gene expression of both IL-6 and CCL5 in LNCaP cells.

We now report that the major human-expressed metallothionein (MT) subtype, MT-2A, is capable of preventing the in vitro copper-mediated aggregation of Aβ1 40 and Aβ1 42.

Mateo and colleagues showed that the antibody-mediated aggregation of the CD47 antigen leads to the induction of a caspase-independent signal responsible of the B-CLL death [35].