Sentence examples for mediated adaptation to from inspiring English sources

Demonstrating long-term epigenetically mediated adaptation to accumulated stress would require a similar approach gene expression profiling.

In summary, the localization of the transcription factor HIF-1α is shifted during the differentiation process from the cytosol (in monocytes) to the nucleus (in macrophages), apparently as a PKC-α/β1- mediated adaptation to a low oxygen environment.

25 Reversing hypoxic-mediated adaptation to cell death signals may also be a critical in targeting hypoxic tumors.

Only a few reports suggested that a HIF-1 inhibitor ARD1 is downregulated during hypoxia and this ensures the HIF-1-mediated adaptation to hypoxia.

However, Tipin depletion does not affect Plx1 binding to chromatin, confirming that Plx1 recruitment to chromatin at the onset of DNA replication takes place through a mechanism distinct from that of Claspin-mediated adaptation to the checkpoint.

Overall, these data indicate that the mechanism responsible for Plx1-mediated suppression of the checkpoint during origin firing is distinct from Plx1-mediated adaptation to the checkpoint at the G2/M transition.

Given that PRC2-mediated H3K27me3 confers stemness and controls the development of organisms by regulating the expression of developmental genes, 66, 67) tumor cells might usurp this epigenetic process to mediate adaptation to tumor environments.

In summary, the ADERS hypothesis states that malignant transformation (along with some other pathologies) is facilitated by epigenetically mediated extreme adaptation to accumulated stress.

Our findings on expression of skeletal and cardiac actin, as well as desmin in OPN−/−-mice, give further support to an osteopontin-mediated adaptation of cardiomyocytes to ischemic injury.

To understand whether 99CGG expression interferes with RNAi-mediated adaptation, we turned to the RNAi defective strain, mut-7 pk204). mut-7 pk204

As a result of the HLA-mediated adaptation of HIV to proteasomal preferences, the CD8 epitopes presented by rare HLA variants are produced in greater quantities than those presented either by common variants or by a combination of rare and common variants and might therefore be more likely to prime (Faroudi et al., 2003) and/or be recognized by CTL (Purbhoo et al., 2004).