Sentence examples for mediated activity of from inspiring English sources

The study of estrogen receptor- (ER-) mediated activity of POPs in MCF-7-ERE cells showed that several organochlorine pollutants (DDT and metabolites and HCH isomers) present an estrogenic activity, which was also confirmed by other authors [ 24, 44– 44].

Our previous studies had also shown that inhibition of AR transactivation is specific, as Ebp1 did not affect the estrogen induced responsiveness of an ERE luciferase reporter or the thyroid hormone mediated activity of a TRE luciferase reporter plasmid (Zhang et al, 2002).

The affinity of PR1A3 Fab for cell-bound CEA is approximately 10 n M. The ADCC mediated activities of mPR1A3IgG1, mPR1A3IgG2a and uhPR1A3IgG1, using human effector cells and SKCO-1 as targets, are illustrated in Figure 2A and B. The data show that uhPR1A3IgG1 kills much more actively than either mPR1A3IgG1 or mPR1A3IgG2a.

Pde2 and Ira2 are both responsible for feedback down-regulation of the cAMP-mediated activity of PKA [ 49]; hence deletion in either encoding gene causes constitutive activation of the cAMP pathway.

Unfortunately, the exact mechanism of the hormone receptor-mediated activity of trans-R is poorly understood because of the apparent complexity of the underlying biological functions of these receptors in prostate cancer cells.

However, it is increasingly recognised that engineering design is not a mechanistic process which can be fully described in a manual, but a complex and elaborate socially-mediated activity of which much is tacit.

Measuring agonist-mediated activity of GRK4 is relatively straightforward since it inhibits second messenger signaling; however, only a few studies have directly examined the constitutive activity of GRK4 which requires techniques without an agonist.

Analysis of a series of deletion constructs of the Hey2 promoter revealed that Foxc-mediated activity of the shortest promoter (0.5 kb) remained almost intact compared with the longer promoter regions (Figure 1C), suggesting that this region is responsible for the induction.

The unique PFAHL motif (within the C1b domain) spanning amino acids 493 509 is indispensable for Gβγ-mediated activity of AC2 [ 46].

The second principal component was associated with the ER-mediated activity of serum extracts (ER-CALUX assay), E2 concentrations, and CYP1A1 and CYP1B1 mRNA expression level.

In addition, elevated levels of lipid hydroperoxides (LPO)—an indicator of increased levels of radical oxygen species, implicate an oxidative stress-mediated activity of NF-kB signaling.