Sentence examples for mediated activity in from inspiring English sources

In this study utilizing peptide grafted to preserve their pharmacophoric recognition motif and assessed their stability and potential to block ERα mediated activity in silico and in vitro.

However, cells transfected with DN showed an approximate 40% decrease in PPRE mediated activity in both untreated and TZD treated cells.

Similarly and in view of the TNFRII mediated activity in vitro in the T-cell compartment, normal development of thymocytes and lymphocytes in TNFRII null mice was quite unexpected [29].

In the present study we measured the integrated AhR mediated activity in the lipophilic serum fraction containing POPs using the mechanistically based AhR-CALUX bioassay.

In addition, unlike aspirin alone, NCX 4016 inhibited tissue factor expression on lipopolysaccharide-stimulated monocytes, suggesting that NCX 4016 has NO mediated activity in addition to COX inhibiting activity [ 51].

Consistent with this interpretation, there was an influx of CD8+ T cells (Fig. 4C), suggesting a role for CD8+ T cell mediated activity in the anti-tumor activity observed.

However, group 3 EDCs did not activate ERβ ERE-mediated activity in HepG2 or HeLa cells.

We pharmacologically altered D1-receptor-mediated activity in the frontal eye field of the prefrontal cortex and measured the effect on the responses of neurons in area V4 of the visual cortex.

In this study, we found that the conserved Arp5 and Ies6 subunits of the Saccharomyces cerevisiae INO80 chromatin-remodeler form an abundant and distinct subcomplex in vivo and stimulate INO80-mediated activity in vitro.

Increased TNFα-mediated JNK signaling in the perivascular adipose tissue (PVAT) may contribute to the pathogenesis of vascular complications in T1DM by reducing adiponectin (Ad) synthesis and therefore impairing Ad-mediated activity in the contiguous blood vessel system.

In this study, we examined cannabinoid-mediated activity in hippocampal area CA1 neurons in brain slices from adolescent and adult rats.