Sentence examples for mediated acquired from inspiring English sources
Considering exogenous FGF2 and FGF7 can rescue anchorage independent growth, human fibroblasts were cultured as feeder layers with H322c cells in an anchorage-independent growth assay to test the role of paracrine-derived FGFs in FGFR mediated acquired resistance.
However, T-cell mediated, acquired immunity also plays a role in protecting against fungal infection [ 23].
However, researchers have found that a heregulin EGFR HER3 autocrine signaling axis mediated acquired lapatinib resistance in HER2+ breast cancer models which no longer depended on HER2 HER3 PI3K signal pathway.
The fruit fly is a useful model to tease out these mechanisms because it has a highly conserved innate immunity but lacks a traditional cell-mediated acquired immunity and the vast adaptability of the human immune system [15] [20].
Our results, however, clearly demonstrate that the PHA-test provokes a greater swelling on the second compared with the first PHA response, a critical requirement if the test is to be considered indicative of a true cell-mediated acquired immunity [23].
They attribute this pattern to the higher prevalence of HPV antibodies in older men and thus antibody-mediated acquired immunity.
To investigate the role of miRNAs in the Axl-mediated acquired gefitinib resistance, we examined the Axl-mediated miRNA changes in gefitinib-resistant lung cancers.
Similarly, Zhao et al. demonstrated that HIF1α-mediated acquired resistance to TK inhibition in BCR-ABL-dependent leukemias engenders enhanced sensitivity to oxythiamine, an inhibitor of both the pyruvate dehydrogenase complex and the non-oxidative pentose phosphate pathway enzyme transketolase [ 2].
We thus attempted to investigate the effect of asbestos on acquired immunity in the antitumor response using the mixed lymphocyte reaction (MLR), an experimental method to induce cell-mediated acquired immunity using an allogeneic set of PBMCs or lymphoid cells, and an easy tool to mimic in vitro induction of CTL function from naïve CD8+ T cells.
The ability to overcome EGFR-mediated acquired therapeutic resistance to lapatinib was demonstrated through molecular knockdown of EGFR and treatment with the irreversible pan-HER TKI neratinib, which blocked HRG-dependent phosphorylation of HER3 and EGFR, resulting in apoptosis of resistant cells.
It is suggested that the resistance to P. sojae conferred by Rps genes is mediated by the SA signaling pathway, with the induction of SA-mediated systemic acquired resistance (SAR) occurring several days post infection (dpi) via expression of the gene NPR1[ 24- 26].
