In conclusion, the MCT-mediated absorption of VPA was significantly decreased by concomitant administration of HQT.
One of us previously documented transporter-mediated absorption from the apical membrane of the intestine of the bat Artibeus jamaicensis [17].
Prodrugs can be prepared to enhance transporter-mediated absorption and to improve metabolic stability.
The βENaC-Tg mouse represents a murine model with CF-like lung disease that mimics an imbalance of CFTR-mediated anion secretion and ENaC-mediated Na+ absorption characteristic of human CF airways.
Clinically, malaria-induced inflammation has been shown to be associated with a hepcidin-mediated reduction in intestinal absorption of iron.
Our findings also predict that there is a significant difference in the absorption of carrier-mediated compounds in the different intestinal segments.
Biotin receptors that distribute in the small intestine and partially in the colon are responsible for the essential absorption of biotin by nonspecific receptor-mediated endocytosis [23].
Besides conventional plastic deformation by dislocation glide within the grains, we also consider grain boundary (GB -mediated deformation and recovery mechanisms based on the absorption of dislocations into GB -mediated
Some authors suggest that physiologic mechanisms, or pharmacologic agents, for example, vasopressors, impair absorption of SC heparin through adrenergic-mediated vasoconstriction of peripheral blood vessels [ 11, 14, 16, 17].
Previously, feeding of C. elegans on bacterial strains expressing dsRNA sequences, has been successfully employed to achieve systemic absorption of the dsRNA, leading to RNAi mediated silencing of the target gene in the nematode [38].
In contrast, there is little data to support significant impact of transporter-mediated intestinal absorption in bRo5 space.
