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Furthermore Asp29' mediated a strong hydrogen bond with oxygen atom of R1 3-phenyloxazolidin-2-one ring with the distance of 1.95Å.
While addition of cultured algae alone led to a rather small effect in fish free enclosures, the presence of fish mediated a strong increase in chlorophyll-a in enclosures with ≥10 fish m−3, probably through intense predation on zooplankton.
We found that hypoxia, but not 20% O2, mediated a strong Wnt3a-induced β-catenin transcriptional activation.
We found that hypoxia mediated a strong upregulation of HIF-1α in the control cells, whereas hypoxia failed to induce HIF-1α levels in MnSOD-kd cells.
As shown in Figure 1a b, the p.K294S_insFPQ mutation identified in this patient mediated a strong imatinib resistance and moderate resistance towards nilotinib and dasatinib.
With a construct containing a trimer of a motif unrelated to FORCA(3xM5-pCAMBIA) we observed no significant reporter gene activity, while a trimer of a second unrelated motif, M6, mediated a strong increase of GUS activity upon SA treatment (see Additional File 2).
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However, stimulation of NPSR1-B mediated a stronger concentration-response on CD69 and no concentration-response on NTS.
Upon induction of these genes, NPSR1-A mediated a stronger response than -B at the early peak of expression (0.5-1 h post NPS stimulation) while at later time points the relative expression difference diminished and was similar to NPSR1-B induction of the same genes.
MGMT-P140K is a clinically relevant selection marker that mediates a strong survival advantage in hematopoietic cells exposed to alkylating agents.
Although a single Ser residue in a transmembrane helix is unable to mediate a strong association of the helices, the cooperative interactions of two or more appropriately placed serine hydroxyl groups per helix has been hypothesized to allow formation of a "serine zipper" that can stabilize transmembrane helix association.
Affinity-purified antibodies against each MSP3-family member were found able to mediate a strong monocyte dependent parasite inhibition in ADCI assay in vitro (Fig. 9).
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