This may be mediated by a reduced intercellular competition for the common γ-chain, and enhanced ligation of IL-2, IL-7 and IL-15, prolonging the proliferative response.
Hypothyroidism resulted in a significant decrease in Smo mRNA levels selectively in the DG, raising the intriguing possibility that the neurogenic decline observed in hypothyroid animals may be mediated through a reduced responsivity to Shh signaling.
Thus, the strongly preserved experience-dependent plasticity in adult rl−/− V1 is not likely mediated by a reduced or loosened extracellular matrix, nor by a defective or absent maturation of PV+-circuits.
However, the decrease in sodium reabsorption after L-NMMA was not mediated by a reduced transport via ENaC, but must be due to L-NMMA induced change in tubular sodium absorption at another location in the nephron.
Sustained Wnt/ β-catenin signaling increases Dll4 in tumor vessels and induces Notch signaling that mediates a reduced angiogenic response and normalizes tumor vasculature [ 67].
It was found that PP-PLLD-Arg/MMP-9 nanocomplex showed the photo-enhanced gene transfection efficiency in vitro, and could mediate a significant reduce of MMP-9 protein expression in HNE-1 cells.
Although the direct effect of smoking on neonatal mortality is weak, its effects (on mortality) appear to be largely mediated through reduced fetal growth and, to a lesser extent, through shortened gestation.
20 A recent clinical trial indicated reduced OA knee pain after treatment with strontium ranelate, an effect that may be mediated through reduced bone turnover.
On the other hand, human ovarian cancer lines that express IL-8 have a reduced tumourigenicity, mediated by an increased accumulation of neutrophils at the inoculation site (Lee et al, 2000).
We found that the pro-angiogenic effects are partly mediated through reduced repression by miR-101 of the histone-methyltransferase EZH2, a member of the Polycomb group family, thereby increasing methylation of histone H3 at lysine 27 and transcriptome alterations.
