Sentence examples for mediated a dose-dependent from inspiring English sources

Staurosporine, on the other hand, mediated a dose-dependent activation of Akt throughout the whole time-course experiment.

MTX mediated a dose-dependent increase in IL-1 and IL-6 in U937 cells, as measured by secreted proteins and levels of gene expression.

This mechanism was found to require CD4 clustering, and to be dependent on the antibodies' Fc region: whole antibody, but not F ab' 2 fragments, mediated a dose-dependent CD4 down-regulation in the presence of monocytes.

Stimulation with FGF2 mediated a dose-dependent upregulation of MMP-13, a significant inhibitory effect on PG accumulation and synthesis, and the inability of BMP7 to stimulate PG production in the presence of FGF2.

Valproic acid mediated a dose-dependent upregulation of PKC kinase activity as indicated by increased p-adducin levels in H460 and H513 cells, whereas there was no discernable alteration of the already high basal p-adducin level in TE12 cells and these were completely abrogated by UCN-01.

These results demonstrate that CXCL12 mediates a dose-dependent cell motility response in LNCaP cells.

LPS-induced activation of macrophages in the indicated media showed that both CSF-1 (Fig.  6c (i)), and CCL2 (Fig.  6c (ii)) mediate a dose-dependent decrease in MHC II levels in response to LPS activation, indicating that CSF-1 plays a dual role in macrophage activation.

The inhibition of glucose uptake was alleviated mediated by a dose-dependent manner in SCC-4 cells with AESN treatment for 24 h, resulting in mitochondrial fission.

Studies employing adult rat hippocampal slices demonstrated that Cr pre-incubation mediates a dose-dependent increase in intracellular PCr, as well as delayed anoxic depolarization and protection against anoxia-induced impairment of protein synthesis and neuronal cell death [78, 79].

Bell et al. demonstrated that nitric oxide can mediate cardioprotection in a dose-dependent fashion by an effect that may be related to mitochondrial membrane potential.

MTX mediated a dose- and time-dependent increase in apoptosis of U937 cells as measured by 7-AAD; HCQ did not show an effect on the apoptosis profile.