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EHDs possess several domains that could potentially mediate various functions.
Chemokines are produced by macrophages, lymphocytes, neutrophils and dendritic cells and mediate various functions of these cells, including recruitment of other cells [47], [48].
Considering that thrombin was shown to mediate various functions unrelated to blood clotting, either directly by cleavage of protease-activated receptors (PARs) or indirectly by cleaving osteopontin (OPN) on stroma cells, the role of PAR1 and PAR4 antagonists as well as treatment with cleaved form of OPN (tcOPN) were tested.
FCGRs can mediate various functions, such as antibody-dependent cellular cytotoxicity and phagocytosis.
Growth-related oncogene- (GRO-) β is a member of the CXC chemokine family, which may mediate various functions, such as attracting neutrophils to sites of inflammation, regulating angiogenesis, and participating in tumorigenesis and progression.
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It was recently revealed that the so-called "E-network" mediates various functions, including sense of self, resting state, ToM, memory recall, and reasoning [16].
FoxO proteins identified in mammals, FoxO1, FoxO3a and FoxO4, constitute a newly characterized subfamily of the Forkhead/winged helix group of transcription factors and play a predominant role in mediating various functions of the PI3K/Akt pathway [16], [17].
Bmpr1a mediates various functions during development of urogenital organs derived from urogenital sinus (19, 20).
Given the location of its expression, it has been suggested that H3R, by modulating the brain histaminergic tone, mediate various CNS functions affecting a variety of behaviors.
Phospholipases are ubiquitous and diverse enzymes that mediate various cellular functions, such as membrane maintenance.
Auto-regulation of phoP likely regulates expression of other genes that mediate various cellular functions such as LPS modification, cell structure [ 26], and type III secretion systems [ 27]. phoP has been previously identified to be involved in virulence as mutational inactivation of this gene rendered P. luminescens avirulent to Spodoptera littoralis larvae [ 6].
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