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Organic anion transporters (Oats in animals/OATs in humans, subfamily of Slc22 drug transporters) mediate transport of endogenous and exogenous organic anions (OA) and play a major role in the uptake and/or secretion of OA in cells of various mammalian organs, mainly in the liver and in the kidneys.
The adenosine triphosphate-binding cassette (ABC) family transporters mediate transport of a wide variety of molecules across biological membranes and play critical roles in plant growth and development.
Accumulative transporters mediate transport of amino acids against an amino acid concentration gradient using secondary active transport dependent on electrochemical gradients.
In particular, the plasmodial hexose transporter, PfHT, known to mediate transport of this essential substrate to the parasite has been a promising candidate for development of inhibitors.
At least four other Na+-dependent carriers exist at the abluminal membrane: system ASC (SLC1A5) alanine, serine, and cysteine preferring, [ 104], system Bo+ (SLC7A3) for basic AAs [ 105], system N (SLC38A5) for nitrogen rich AA (glutamine, asparagine, and histidine) [ 106], and excitatory amino acid transporters (EAAT) (SLC1A1-3), that mediate transport of aspartate and glutamate [ 107].
Glucose transporters GLUT 1 and GLUT 3 mediate transport of DHA (Vera et al. 1993), whereas ascorbic acid enters cells through sodium-dependent transporters SVCT1 and SVCT2 (Takanaga et al. 2004).
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These transporters are ATP-dependent drug efflux pumps mediating transport of endogenous and xenobiotic substances.
This large supramolecular assembly mediates transport of cargo into and out of the nucleus and fuse the inner and outer nuclear membranes to form an aqueous translocation channel.
FcRn also mediates transport of intact IgG across polarized epithelial barriers, a pathway that is attractive for delivery of Fc-containing therapeutics.
FcRn also contributes to passive immunity by mediating transport of IgG from mother to fetus (human) or newborn (rodents), and may translocate IgG over mucosal surfaces.
B. anthracis produces two binary exotoxins, lethal (LT) and edema toxins (ET) [9-11], eaconsistinging of a toxic moiety [lethal factor (LF) and edema factor (EF), respectively] and protective antigen (PA), which mediates transport of the toxic moieties into host cells.
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