Sentence examples for mediate translation from inspiring English sources

A critical outcome of mTOR activation is the phosphorylation of several components of the translational apparatus, which mediate translation initiation and cell proliferation.

We show how to develop such an ontology and use it to mediate translation through a real scenario where water resources data have to be translated to a standard data transfer format.

In both yeast and metazoans, TOR proteins mediate translation in response to nutrients [ 7].

Upstream ORFs are common elements of plant transcript sequences and have been shown to mediate translation for a number of genes (reviewed in [ 22]), including transcription factors [ 23, 24] and enzymes involved in polyamine biosynthesis [ 25].

Previous studies have shown that the ribosomal protein S1 acts independent of an SD sequence, and binds to non-SD motifs to mediate translation initiation in E. coli [ 13, 18]; however, the S1 protein does not appear to be essential in many other prokaryotes [ 19].

To determine if GLV IRES requires a pre-initiation complex for translation initiation, we tested 5' capped dicistronic constructs in RRL in the presence of edeine and we found that the GLV IRES mediated translation was unaffected up to 0.5 µM of the drug (Fig. 4C), whereas the cap-mediated as well as the EMCV IRES mediated translation was inhibited by edeine in a dose dependent manner (Fig. 4A).

Furthermore, a recent study found that translation in mitosis is dominantly cap-dependent (Shuda et al., 2015), suggesting that IRES-mediated translation may only make a minor contribution to the translational landscape in mitosis.

These two modes of ribosome recruitment are distinguishable by using the translation initiation inhibitor edeine that prevents the recognition of the initiation codon by a pre-initiation complex in RRL [53], [54], thereby inhibits the cap-mediated and EMCV IRES driven but not the CrPV IRES and HCV IRES mediated translation initiation [51], [52], [55].

In the present study, we confirmed that eIF4E2 is required for miRNA mediated translation repression.

A very recent research shows that eIF4E2 effects miRNA mediated translation silencing by competing with eIF4E for binding 4E-T (Chapat, 2017).

For poliovirus IRES-mediated translation, the interaction of the cellular protein PCBP2 with a major secondary structure element (stem-loop IV) is required for gene expression.