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In E. coli, three systems are known that mediate tolerance to copper ions.
The concept that Nod2 may mediate tolerance to stimulation of other receptors such as TLRs has recently been proposed.
Special intestinal macrophages (IMACs) mediate tolerance to beneficial gut bacteria.
More important from an economical point of view is the fact that many insect ABC transporters mediate tolerance to xenobiotics.
Bacteria can also mediate tolerance to antibiotics independent of genetic change, such as with persister states or biofilm formation.
To address to what extent As, Cd and various oxidants have overlapping toxicity profiles, we compared our gene sets with a set of genes previously reported to mediate tolerance to a number of ROS-generating agents including hydrogen peroxide, menadione, cumene hydroperoxide, diamide, and linoleic acid 13-hydroperoxide [ 70].
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Contact hypersensitivity (CHS) reactions depend on the interaction of mast cells and DCs [37], and the mast cell-DC interaction is also critical in mediating tolerance to autologous antigens in the skin [38].
Generation of this knowledge together with our ability to manipulate genes involved in mediating tolerance to various stressors including low temperature will lead to the development of cold-resistant genotypes.
The HLA-G molecule due to its many unique features and its immuno-modulatory abilities is now well recognized to play a central role in mediating tolerance to the semi-allogenic fetus by the maternal immune system.
Although cumulative evidence from experimental animal models has demonstrated that adequate apoptotic cell clearance plays a role in mediating tolerance to apoptotic cells and preventing autoimmunity [9] [16], in human SLE, the possible pathogenic consequences of an abnormal interaction between apoptotic material and phagocytic cells remains unclear.
Additionally, the two-component response regulator VraR was suggested to be important for mediating tolerance to antimicrobial peptides.
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