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P mediates acute inflammatory signaling, while Dr, S, and Type 1 may mediate tissue invasion.
E. coli bearing afa/ dr genes coding Dr and Afa adhesins originate from the gastrointestinal tract as the host's intestinal microflora [ 31], mediate tissue invasion and can cause chronic urinary tract infections and bacteraemia [ 30– 30].
This observation implies that E. coli bearing P fimbriae with the capacity to cause severe inflammatory response and an adhesin which can mediate tissue invasion may establish an effective translocation strategy for passing all tissue barriers in order to access the bloodstream and cause bacteremia.
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The ECM-binding integrins mediate cellular processes such as adhesion, migration, tissue invasion, and chemotaxis but also cytokine and MMP production.
Tumor cell dissemination is mediated by a number of mechanisms, including local tissue invasion, lymphatic spread, hematogenous spread, or direct seeding of body cavities or surfaces.
Environmental chemicals, such as tetrabromobisphenol A and its metabolites, BPA and tetrabromobisphenol A dimethyl ether, which mediate the activation of EMT enzymes or drive their synthesis, may also contribute to the process of tissue invasion (415).
Following primary infection, the cell mediated immunity prevents reinfection by confining of the larvae and the adult form to the intestine and preventing the tissue invasion in immunocompetent persons, but autoinfection is exaggerated in immunosuppressed ones and contributes to hyperinfection [ 1].
Moreover, such genetic diversity permits exploitation of tissue ecologies through increased proliferation, migration and tissue invasion.
On CT, free air with evidence of soft tissue invasion is consistent with the diagnosis [2].
The Gal/GalNAc lectin is an adhesion protein complex which sustains tissue invasion by E. histolytica.
FrpC is involved in tissue invasion of N. meningitidis [84].
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