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Together these results highlight the multiple activities of IL-23 that mediate tissue inflammatory responses (Fig 1).
Although endotoxin is involved in several clinical conditions, such as sepsis and systemic inflammatory response syndrome, it is only one of the multiple factors that mediate tissue inflammatory responses and injury seen in the clinical settings.
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Recent studies have implicated the neuronal guidance molecule netrin-1 in mediating tissue inflammatory responses.
CCL17, another previously unreported glucocorticoid-induced chemokine, is a marker and promoter of the polarization of 'alternatively activated' M2 MФ, which are considered anti-inflammatory and mediate tissue repair and wound healing [ 49, 50].
Consequently, in AKU the chronic accumulation of HGA and its auto-oxidized derivatives may initiate a variety of reactions that promote inflammatory responses and mediate tissue damage.
Although this response is helpful at initially protecting from invading pathogens, prolonged neutrophil responses mediate tissue damage in multiple organs under inflammatory conditions (Fukushima et al. 1995; Partrick et al. 2000).
As resident brain macrophages, microglia function as sentries, but when activated they can mediate tissue damage, a scenario considered for several CNS inflammatory disorders (10, 15, 27).
P mediates acute inflammatory signaling, while Dr, S, and Type 1 may mediate tissue invasion.
DAMPs modulate inflammatory responses in infectious and non-infectious conditions to mediate tissue repair.
In parallel, these inflammatory factors stimulate the production of growth factors such as VEGF and mediate tissue repair [ 47].
RA-FLSs not only mediate tissue destruction but also are considered to play a major role in initiating and driving RA in concert with inflammatory cells [ 7].
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