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IL-1 enhances the proportion of responding CD4 T cells that differentiate into Th17 cells and increases the proportion of responding CD8 cells that express granzyme B. Of a wide range of cytokines tested, only IL-1α and IL-1β mediate this function.
APPL over-expression induced synaptic bouton formation could be prevented by deletion of the C-terminal domain or the N-terminal E1 and E2 domains, showing that the holoprotein is needed to mediate this function [45].
Both cellular and humoral components of innate immunity mediate this function (Fig. 1).
The wide pattern of projections of the orexin neurons throughout the brain could mediate this function.
The precise mechanism by which cytoskeletal and intracellular elements mediate this function are being characterised.
This study describes the specific, key integrins and adhesion molecules which mediate this function in an oxygen concentration-dependent manner.
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We therefore wondered whether IL-6 and IL-1 cooperate in mediating this function.
The crucial involvement of Vinculin at radial actin contacted FAJs shows that force-generated signaling at the Cadherin complex mediates this function of actomyosin.
Intriguingly, HP1E is able to mediate this priming function transgenerationally i.e., the HP1E protein itself is not epigenetically inherited.
The paralogs may present alternative routes by which parasite lines carrying different pfcrt alleles could mediate this essential function.
There are many genes in the region of the rs646776 locus (Figure S3), and CELSR2, PSRC1 and SORT1 genes have been suggested to mediate the function of this SNP (or functional SNPs in LD [11], [18] [20].
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