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Future studies are required to understand the microglial receptors for Aβ peptides that mediate these responses and whether Aβ peptides induce similar anti-microbial responses from other cell types.
We hypothesized that these features developed because of differences in fluid-induced shear stresses due to substrate architecture and that integrins mediate these responses.
This suggests that one or several of the DILPs of the IPCs mediate these responses.
Collectively, these results directly demonstrate that Merkel cells are activated by hypotonic-evoked swelling, identify cellular signaling mechanisms that mediate these responses, and support the hypothesis that Merkel cells contribute to touch reception in the Merkel cell-neurite complex.
Thus, these studies demonstrate M. pulmonis recognition is mediated by TLR2 and suggests that M. pulmonis expresses both di- and triacylated lipoproteins on its surface, which mediate these responses.
In vitro, LAP required TSP-1 and CD36 to recruit monocytes, while other ligands that interact with TSP-1, like RGD peptides and CD47, did not appear to mediate these responses.
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To assess molecular mechanisms mediating these responses, we analyzed the effects of the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide, on EpiDerm-FT™, a commercially available full-thickness human skin equivalent.
Conventional approaches to classify molecular factors mediating these responses have targeted relatively few biological measurements or explored cross-sectional study designs, and therefore have restricted characterization of stress immune interactions.
The present study was thus designed to examine: 1) whether there are vasodilator fibers in the masseter muscle ; and 2) if there are, to elucidate the neural pathways mediating these responses in urethane-anesthetized rats.
Although endothelin-1 can elicit prolonged physiologic responses, accumulating evidence suggests that rapid desensitization affects the primary G protein-coupled receptors mediating these responses, the endothelin A and B receptors (ETA-R and ETB-R).
The molecular mechanism mediating these responses is under investigation.
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