The presented results show that p85β in complex with FAK localizes at cell adhesions and mediates their stabilization, maturation, and z-axis actin polymerization.
Wnts mediate their intracellular effects by inducing stabilization and nuclear translocation of β-catenin.
Although the supramolecular organization of the respiratory chain complexes has been extensively documented in different model organisms, the existence of factors mediating respirasome assembly or their stabilization have remained elusive (Schägger and Pfeiffer, 2000, 2001).
This study indicates that Ang1 may mediate vascular stabilization by acting on the mesenchymal component of the tumour.
The paper also concludes that one of the functions of Scc4 is to mediate Scc2 stabilization, a statement for which there was no adequate justification.
Because of their important roles in mediating the stabilization and expression of p53, we hypothesized that high-risk genotypes of polymorphisms in p53-related genes, including p53, p73, p14 ARF), MDM2 and MDM4, may be associated with an increased risk of second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN).
B56 γ is also known to mediate dephosphorylation and stabilization of the tumor suppressor protein p53 upon DNA damage, inhibiting cellular proliferation and transformation.
Phosphorylation can affect the function of a protein in many ways by increasing or decreasing its activity, mediating translocation between subcellular compartments, initiating/disrupting protein protein interactions, or affecting their stabilization in signaling pathways [ 6].
Therefore their stabilization is required.
This work showed that the MUC1-C cytoplasmic domain is sufficient to induce anchorage-independent growth and tumorigenicity and that this effect is partly mediated by stabilization of β-catenin.
