However, genes mediate their biological roles in groups rather than in isolation, prompting us to extend the concept of eQTLs to whole gene pathways.
Taken together, these studies suggest that Th17 cells might play a role in the breach of immune tolerance, pointing to a new mechanism mediating their pathogenic role in autoimmunity.
The phenomena of shedding 'exosomes' have also been demonstrated with other haematopoietic cells, such as mast cells and platelets, and it is thought to play important roles mediating their actions (Raposo et al, 1997).
The molecular cues present within the microglial microenvironment play a crucial role in mediating their activation phenotype.
The effects of statins on lipids beyond those exerted via LDL-C reduction may play a substantial role in mediating their cardiovascular benefits.
The ERK1/2 MAP kinase pathway is constitutively activated in most melanoma cells, where it plays a major role in mediating their survival and proliferation (Hue et al, 2005).
Behaviour change was heavily influenced by peoples' first-hand experience of AIDS deaths, backed up by prevention programmes, with interpersonal communication playing a key role in mediating their impacts on behaviour (Halperin et al., 2011; Muchini et al., 2011).
This alteration is partially heritable through the F1 generation and is thought to play a role in mediating their resistance to teratogenicity and lethality caused by PAHs (Meyer and Di Giulio 2002; Meyer et al. 2002).
It has been proposed that the ability of covalent poisons to close the N-terminal gate plays an important role in mediating their ability to increase levels of topoisomerase II DNA cleavage complexes.
All of these environmental factors are associated with elevated levels of reactive oxygen species (ROS) (Aoto et al., 2008; Davis et al., 1990; Kay et al., 2000; Ornoy, 2007), suggesting that oxidative stress has a role in mediating their teratogenic effects.
