Sentence examples for mediate their inhibitory from inspiring English sources

A considerable number of experiments performed in vitro have shown that Treg cells depend on direct cell-cell contact to mediate their inhibitory activity, and have suggested that the major mechanisms described (inhibitory cytokines, cytolysis and metabolic disruption) act directly on the effector T cell (reviewed in[8]).

However, these compounds mediate their inhibitory activity at ⩾60 μℳ, and show little MM cell apoptosis induction as single agents.

Both inhibitor proteins have acidic tails through which they may mediate their inhibitory effect on the phosphatase.

The question arises for the target sites at which Ro5-4864 and other 1,4-benzodiazepines mediate their inhibitory effects on MCs.

Dopamine D2 receptors mediate their inhibitory signaling through inactivation of ERK1/2 (Liu et al. 2002), explaining why bromocriptine treatment down-regulated Ccnd1.

Importantly, studies have shown that CSPGs interact with adhesion molecules expressed on various cell types, mediating their inhibitory effects via the surface receptor protein tyrosine phosphatase sigma (PTP σ) that is found on both neurons and OPCs [ 49, 60– 63].

Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-β-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production.

This inhibition was partially lost in Megf8 −/− explants, indicating that TG neurons require Megf8 expression to mediate their maximal response to the inhibitory effects of BMP4.

These observations support the evidence that inhibition of head and neck cutaneous squamous cell carcinoma cell invasion by GSPs is mediated through their inhibitory effects on EGFR expression.

γ-Aminobutyric acid (GABA) receptors (GABARs) mediate fast inhibitory synaptic transmission and are also targets for drugs and insecticides.

Considering these contrasting findings, it should be investigated whether metabolites produced during PHS activation, rather than propofol per se, can mediate an inhibitory effect on CSD.