We showed that the formation of filopodia containing actin filaments along their entire length depends on motifs contained in LIN7 and IRSp53 that mediate their association and filopodia tip localization.
Both proteins contain ankyrin repeats, a PP1 catalytic subunit (PP1c) binding motif and a C-terminal prenylation motif; the latter one mediates their association with the plasma membrane [ 3].
A rather long helix of the cobalamine riboswitch is kinked by its K-turn [7], while the K-turn of the glycine riboswitch connects the two aptamer domains mediating their association that leads to cooperative ligand binding [10].
The transfer and deposition of histone variants into chromatin is mediated via their association with specific histone chaperones.
We had previously found these sites to be associated with T2D [ 30], and next considered whether this is mediated through their association with HTGW.
Here, we investigate the association of birth weight, birth length, childhood height and body mass index (BMI) with psychosis-like symptoms at age 12 and whether any association between these measures and psychosis-like symptoms is mediated through their association with IQ.
This suggests that all three family members recognize the same binding site on RNA mediating their polyribosome association, and that they may be functionally redundant with regard to this aspect of translational control.
A thorough understanding of how the functional variants underlying these associations mediate their effects is likely to yield rich rewards not only in terms of understanding tooth eruption and craniofacial development, but also potentially about how disease develops across the life course.
Downstream of integrins, Crk proteins can mediate migration through their association with the scaffold protein, p130Cas and the Rac exchange factor Dock180 [ 34].
Thus, caveolae domains may play a necessary and significant part in GPCR signaling by mediating GPCR oligomerization, their association with agonists, and their interaction with intracellular G-proteins.
