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Blood concentrations of endothelin-1, a potent vasoconstrictor, could mediate the vascular effects of CAP exposure.
These vasodilators are likely to interact, mediate the vascular tone locally, and act as signaling molecules.
Through activating cGMP-dependent protein kinase (PKG), cGMP is able to mediate the vascular muscle relaxation.
Although either AhR1 or AhR2 can mediate the vascular induction of CYP1A by chrysene, the epidermal induction of CYP1A by chrysene is AhR2 specific.
Furchgott and coworkers [ 13] also identified a vascular relaxant factor, which they called endothelial-derived relaxing factor, and which they thought might mediate the vascular relaxation in response to substances such as bradykinin, histamine, ATP, and ADP.
It is possible that oxidative stress could also mediate the vascular damage of patients with psychosis as it has been established that patients with psychosis are at higher risk of developing cardiovascular diseases [ 63] and diabetes [ 64].
Similar(54)
Nitric oxide plays a vital role in mediating the vascular adaptations during pregnancy.
Our study identified several differentially expressed proteins mediating the vascular smooth muscle contraction and also highlighted the differences associated with the treatment of individual enantiomer.
Our previous studies investigated the intracellular proteome in A7r5 cells incubated with individual enantiomers of β-blockers and identified differentially expressed proteins mediating the vascular smooth muscle contraction [8], [9], [10].
This work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite.
ROS were scavenged with SOD to determine if oxidative stress mediates the vascular changes of DE exposure.
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