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2. Identification of new pathways that mediate the uptake and transcytosis of low density lipoprotein (LDL) and determining how LDL receptor influences vascular disease.
Organic anion transporting polypeptide 1B1 (Oand1B1) and OATP1B3 are human hepatocyte transporterS that mediate the uptake of various endogenous and exogenous substances.
Drug transporters mediate the uptake and elimination of drugs in various organs; therefore, having knowledge of how a transporter functions in the body would play a key role in ensuring drug efficacy in in vivo systems.
The outer membrane (OM) of Gram-negative bacteria contains a large number of channel proteins that mediate the uptake of ions and nutrients necessary for growth and functioning of the cell.
Crucial components of this system are lipoprotein receptors in the liver and extrahepatic tissues that mediate the uptake and degradation of cholesterol-carrying lipoproteins.
The transporters mediate the uptake of different organic anions, including SMF, from the blood stream as their substrates and are concentrated into tubular cells, which mostly affect the proximal tubules [31].
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Here, we show the role of the cellular prion protein (PrPC) in mediating the uptake and the spread of recombinant α-Syn amyloids.
Folate targeting ligand mediated the uptake of NPs into tumor cells.
SLC13A5 mediates the uptake of citrate into cytosol across the plasma membrane with high specificity.
Receptors for maleylated or acetylated proteins as well as for alpha-2-macroglobulin-protease complexes on macrophages serve as scavengers by mediating the uptake of macromolecules from the extracellular compartment.
It is well known that organic anion-transporting polypeptide (oatp) 1 mediates the uptake of Gd-EOB-DTPA and multidrug resistance-associated protein 2 (mediatesdiates biliary excretion of Gd-EOB-DTPA in rats [31],[32].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com